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KMID : 1007520140230041335
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Food Science and Biotechnology
2014 Volume.23 No. 4 p.1335 ~ p.1339
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Anti-diabetic Potential of a Sasa quelpaertensis Nakai Extract in L6 Skeletal Muscle Cells
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Yoon Seon-A
Kang Seong-Il
Shin Hye-Sun
Ko Hee-Chul
Kim Se-Jae
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Abstract
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The anti-diabetic potential of a Sasa quelpaertensis Nakai extract (SQE) in L6 muscle cells was evaluated. The SQE stimulated glucose uptake via the AMP-activated protein kinase-activating pathway, but not via the insulinstimulating pathway. The SQE increased the expression of fatty acid translocase and peroxisome proliferator-activated receptor γ, and induced phosphorylation of acetyl-CoA carboxylase. The SQE attenuated oleic acid-induced intracellular triglyceride contents by decreasing the expression of sterol regulatory element-binding protein-1c and fatty acid synthase. These results indicate that the SQE probably has an anti-diabetic potential by enhancing glucose uptake and reducing triglyceride content in L6 skeletal muscle cells.
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KEYWORD
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Sasa quelpaertensis Nakai, L6 skeletal muscle cell, anti-diabetic, glucose uptake, lipid accumulation
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